Detalhe da pesquisa
1.
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B.
Bioorg Med Chem Lett
; 68: 128764, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504513
2.
Proteomic research and diagnosis in bladder cancer: state of the art review.
Int Braz J Urol
; 47(3): 503-514, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-32459456
3.
NLRP3 gain-of-function in CD4+ T lymphocytes ameliorates experimental autoimmune encephalomyelitis.
Clin Sci (Lond)
; 133(17): 1901-1916, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471462
4.
Acute exercise elicits differential expression of insulin resistance genes in the skeletal muscle of patients with polycystic ovary syndrome.
Clin Endocrinol (Oxf)
; 86(5): 688-697, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28177124
5.
Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery.
Hum Genomics
; 10: 2, 2016 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26742487
6.
IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
J Biol Chem
; 288(15): 10860-9, 2013 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23447528
7.
NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection.
Pharmaceutics
; 16(3)2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543321
8.
Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia.
Mol Neurobiol
; 59(5): 3170-3182, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35278208
9.
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival.
Clin Epigenetics
; 14(1): 68, 2022 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35606887
10.
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Nat Rev Chem
; 6(4): 287-295, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35783295
11.
Design, synthesis and antihypertensive evaluation of novel codrugs with combined angiotensin type 1 receptor antagonism and neprilysin inhibition.
Eur J Pharm Sci
; 159: 105731, 2021 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33493668
12.
Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats.
J Med Chem
; 64(4): 1904-1929, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33626870
13.
Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.
Neoplasia
; 23(4): 439-455, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33845354
14.
Comparative bioinformatics analysis of prognostic and differentially expressed genes in non-muscle and muscle invasive bladder cancer.
J Proteomics
; 229: 103951, 2020 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32860965
15.
Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin.
Neurobiol Stress
; 13: 100226, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32478146
16.
The serotonergic and alpha-1 adrenergic receptor modulator ACH-000029 ameliorates anxiety-like behavior in a post-traumatic stress disorder model.
Neuropharmacology
; 164: 107912, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31843397
17.
Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis.
Clin Epigenetics
; 12(1): 127, 2020 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32831131
18.
Preclinical characterization of ACH-000029, a novel anxiolytic compound acting on serotonergic and alpha-adrenergic receptors.
Prog Neuropsychopharmacol Biol Psychiatry
; 95: 109707, 2019 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31330215
19.
Transcriptome Analysis of Mesenchymal Stem Cells from Multiple Myeloma Patients Reveals Downregulation of Genes Involved in Cell Cycle Progression, Immune Response, and Bone Metabolism.
Sci Rep
; 9(1): 1056, 2019 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30705326
20.
Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2.
ACS Med Chem Lett
; 10(9): 1266-1271, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531195